Copper(II)‐Catalyzed Aminohalogenation of Alkynyl Carbamates
نویسندگان
چکیده
A useful aminohalogenation reaction for the cyclization of O-alkynyl carbamates under copper catalysis has been developed. N-Halosuccinimides have used as a halogen source. The intramolecular C−N bond formation occurs selectively affording haloalkylidene substituted heterocycles. Just in case α,α-cyclohexyl-substituted propargyl carbamate, alkoxyhalogenation pathway was operative. mechanism two alternative pathways investigated by modeling corresponding transition states at DFT level.
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2021
ISSN: ['1434-193X', '1099-0690']
DOI: https://doi.org/10.1002/ejoc.202100202